Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 6th International Conference on Advanced Clinical Research and Clinical Trials Zurich, Switzerland .

Day 1 :

Keynote Forum

Lora Black

Sanford Research, USA

Keynote: Building a robust oncology clinical research program in the community-based setting

Time : 10:05-10:35

Conference Series Clinical Research 2018 International Conference Keynote Speaker Lora Black photo
Biography:

Lora Black has professional experience practicing as an Oncology Nurse for over fifteen years, twelve of which focused around oncology clinical research. She has held various positions within the clinical research department at Sanford during her tenure, and currently serves as Senior Director. As Senior Director, she has oversight and responsibility for clinical research performed across the Sanford footprint, which covers six states in the rural Midwest and far-reaching collaborations with national and international health care entities. She provides leadership and strategic vision for clinical research team as well as day-to-day guidance of operations. She holds certifications as an Oncology Certified Nurse and Certified Clinical Research Professional. She completed an MPH from Creighton University with a concentration in Health Policy and Ethics. She is also a Faculty Member for the biomedical ethics program at the South Dakota Sanford School of Medicine.

Abstract:

Although 85% of cancer patients in the United States are treated within the community-based setting, opportunities for advanced treatment options via clinical trials are lacking. The National Comprehensive Cancer Network (NCCN) Guidelines state “NCCN believes that the best management for any patient with cancer is a clinical trial. Participation in clinical trials is especially encouraged” (NCCN 2018). To address the need for clinical trials in the rural communities served by Sanford Health, efforts described here were employed over the last five years to develop and maintain a robust portfolio of clinical trials for physicians to utilize as innovative treatment options. Successful approaches to cultivating an oncology clinical research program include (but are not limited to): developing a relationship with clinical operations, administration, physicians, support staff, research staff, and external partners. Formal trial selection through a protocol review and monitoring committee ensures physician engagement in the process of building a trial portfolio, and assists the study team in identifying feasibility concerns at the outset of considering the trial at the site. Furthermore, leveraging efficiencies of an integrated health care system are critical for study-start up, data collection, and subject coordination – all of which contribute to a site’s ongoing ability to remain attractive for future site selection. In addition, utilizing existing infrastructure for patient care management to screen eligible patients for trial significantly increases institutional enrollment percentages. The complexities of a clinical trial program focused in oncology are wide and varied. However, building a program is not impossible as long as the appropriate commitment, strategy, and dedication of resources are applied.

Keynote Forum

Janett Jalil

Invictus Clinical Research Group, LLC, USA

Keynote: Telemedicine: Its applications and the new era of clinical research
Conference Series Clinical Research 2018 International Conference Keynote Speaker Janett Jalil photo
Biography:

Janett Jalil obtained her Medical Doctor degree at the Medical Sciences Institute Carlos J. Finlay in Camaguey Cuba. She completed her residency program in Internal Medicine at the same university three years later. She is the Owner and Director of School of Clinical Research USA, LLC, a clinical research site founded in 2010 to conduct industry sponsored clinical research trials and to promote community awareness about clinical research. Most recently, she was invited as an International Jury Member for the European division of the Videomed 2016 medical education media competition.

Abstract:

Telemedicine has changed the face of medicine in the latest years. The number of physicians applying this technology to facilitate
patient access to their services from anywhere around the globe, at any time of the day, is steadily increasing. The potential
applications of this technology in clinical trials are an exciting prospect. Although some major pharmaceutical companies and large
research centers have spearheaded the implementation of telemedicine platforms as part of their common practices, its use has not spread to smaller settings. The potential benefits derived from expanding the use of telemedicine in clinical trials cover critical areas such as safety reporting, data quality, data review and monitoring, among others. At the site level, this means an improved patient experience, and minimal-error, real time data reporting to sponsors.

Conference Series Clinical Research 2018 International Conference Keynote Speaker Khalid Abou Farha photo
Biography:

W O Chu has graduated from the Department of Pharmacy Taipei Medical University (TMU) and Institute of Biomedical Engineering National Yang Ming University. She is an Adjunct Instructor at TMU and a Pharmacist in Taipei City Hospital, Department of Pharmacy. She has published more than 10 papers in the journal of Taiwan, 2 posters in International Pharmaceutical Federation (FIP), 1 poster in European Association of Hospital Pharmacists (EAHP), and got best poster award in the international pharma and clinical pharmacy congress.

Abstract:

Conference Series Clinical Research 2018 International Conference Keynote Speaker Moawiah Khatatbeh photo
Biography:

Moawiah Khatatbeh has his expertise in public health and epidemiology and passion in improving the health and wellbeing. His philosophy is that our health is within the reach of our hands. In other words, most of health problems are avoidable. He has built this philosophy after years of experience in research, evaluation, and teaching both in hospitals and education institutions.

Abstract:

Keynote Forum

Zaid Altaany

Yarmouk University, Jordan

Keynote: The effect of long term exposure of H2S gas on anti-inflammatory action

Time : 10:35-11:05

Conference Series Clinical Research 2018 International Conference Keynote Speaker Zaid Altaany photo
Biography:

Zaid Altaany has completed his PhD in 2013 from Canada. After his PhD he perused his postdoctoral training in the Department of Biochemistry at Schulich School ofMedicine & Dentistry, Western University, Canada. After completion of his postdoctoral training he was appointed as an Assistant professor in the Department of Medical Laboratory Sciences at Al Balqa University for one year. He was then appointed in 2016 as an Assistant Professor in the Department of Medical Sciences at the Faculty of Medicine at Yarmouk University in Jordan until know. His interests are focused on gasotransmitters, including hydrogen sulfide and nitric oxide and their impact on human health and cell signaling.

Abstract:

Keynote Forum

Osama Abo Alrob

Yarmouk University, Jordan

Keynote: Synergistic beneficial effects of resveratrol and diet on type 2 diabetes mellitus

Time : 11:45-12:35

Conference Series Clinical Research 2018 International Conference Keynote Speaker Osama Abo Alrob photo
Biography:

y of Alberta (PhD in basic medical sciences). I was supervised by Prof. Gary Lopaschuk and our lab is interested in heart and metabolic diseases such as obesity and diabetes. Currently, i am assistant professor in faculty of pharmacy. I teach courses related to Physiology and Pathophysiology.

Abstract:

Keynote Forum

Kaushal Kapadia

Merck Specialties Pvt Ltd, India

Keynote: Perception about clinical trials/clinical research among people in Indian subcontinent

Time : 11:15-11:45

Conference Series Clinical Research 2018 International Conference Keynote Speaker Kaushal Kapadia photo
Biography:

Kaushal Kapadia is an expert clinical research professional with an experience of more than 10 years in clinical research operations. Apart from that an author for the book titled “Perspective on Clinical Research, India” also a best poster award winner at an international conference organized by OMICS in the year 2015 organized in Florida,
USA.

Abstract:

Keynote Forum

Sarnai Arlud

Sarnai Arlud

Keynote: Mongolian mind-body interactive psychotherapy with psoriasis

Time : 10:05 - 11:50

Conference Series Clinical Research 2018 International Conference Keynote Speaker Sarnai Arlud photo
Biography:

Sarnai Arlud has a passion for the mind body interaction. She is focused on evaluating the use of Mongolian mind body interactive psychotherapy in insomnia and psoriasis, and also helping the group assess Mongolian mind body interactive psychotherapy in esophagus cancer, gastric cancer, ulcerative colitis, hyperthyroidism, rheumatoid arthritis, fatty liver, depression, anxiety, hyperplasia of mammary glands, chronic fatigue syndrome, and anti-aging. In addition to this, she is working at understanding the molecular mechanism of Mongolian mind body interactive psychotherapy in psoriasis and its possible function of symptom reaction

Abstract:

Keynote Forum

Lora Black

Sanford Research, USA

Keynote: The need for integrating natural histories into EHRs for more accurate diagnosis

Time : 11:15-11:45

Conference Series Clinical Research 2018 International Conference Keynote Speaker Lora Black photo
Biography:

Abstract:

Conference Series Clinical Research 2018 International Conference Keynote Speaker Amer Hayat Khan photo
Biography:

Amer Hayat Khan joined Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, as a Senior Lecturer. He is involved in teaching (Undergraduate Pharmacy & Master in Clinical Pharmacy i.e. M.Pharm) and hospital visits regarding pharmacy students clerkships. He is also involved in research supervision of PhD’s, Master’s either in Pharmacy and/or Medical students’ research project, community activities, university services etc. He is a Journal Editor and a Reviewer. He shared his skill and research on international platform as a resource person for workshop or as an invited speaker in a conference. In addition to this, he is a Visiting Staff for Chronic Kidney Disease & Resource Center, Hospital USM. Furthermore, he is also acting as a Program Consultant and Visiting Staff for Pharmacy Department at Quaid-e-Azam University, Islamabad, Pakistan. He has supervised 5 PhD’s and 19 Master’s students by research and/or course work research project, while 6 researchers are reaching to defence, whereas 5 are under active supervision. All research projects are published and or publishing in indexed journal.

Abstract:

Keynote Forum

Anil Batta

Government Medical College, India

Keynote: Trends driving clinical trial innovation

Time : 11:45-12:35

Conference Series Clinical Research 2018 International Conference Keynote Speaker Anil Batta photo
Biography:

Abstract:

Conference Series Clinical Research 2018 International Conference Keynote Speaker Buavaroon Srichaikul photo
Biography:

Abstract:

Keynote Forum

Abdeen Omerb

Ministry of Health, Sudan

Keynote: The efficiency of inefficiency: Medicine distribution in Sudan

Time : 11:15-11:45

Conference Series Clinical Research 2018 International Conference Keynote Speaker Abdeen Omerb photo
Biography:

Abdeen Mustafa Omer is an Associate Researcher at Occupational Health Administration, Ministry of Health and Social Welfare, Khartoum, Sudan. He has been listed in the book WHO’S WHO in the World 2005, 2006, 2007 and 2010. He has published over 300 papers in peer-reviewed journals, 200 review articles, 7 books and 150
chapters in books.

Abstract:

Keynote Forum

Clérin E Yang Y

Institut de la Vision, France

Keynote: The development of a therapy for retinitis pigmentosa based on the nucleoredoxin like-1 gene

Time : 10:35-11:05

Conference Series Clinical Research 2018 International Conference Keynote Speaker Clérin E Yang Y photo
Biography:

Clérin E is a Research Engineer and her main expertise is in the fields of animal experimentation, gene therapy, tissue culture, immunohistochemistry and biochemistry. She is managing the research activities of the team. She has developed an automated counting platform at the institute of vision, e-conome to measure cone density over the whole mouse retinal surface. This system, developed as a part of the translational research projects on RdCVF was used in the majority of the team projects in a total of six publications. Also, her main mission is focused currently on this preclinical research project and to assume daily the organization, the follow-up and the feasibility of the totality of the experiment.

Abstract:

  • Clinical Research | Innovations in Pre-clinical Research | Design of Clinical Studies and Trials | Clinical Data Management and Statistics | Stem Cell & Oncology Clinical Research | Innovations in Clinical Trials | Clinical Trials on Different Diseases | Clinical Trials in Developing Countries | Bioethics and Quality Regulation
Location: Athens

Chair

Zaid Altaany

Yarmouk University, Jordan

Co-Chair

Kaushal Kapadia

Merck Specialties Pvt Ltd, India

Biography:

Abstract:

Antibacterial activity of some Palestinian plants against seven human pathogenic bacteria using the agar disk-diffusion method was studied. Evaluation of the antibacterial activities of plant saps based on the width of the bacterial inhibition revealed that Eucalyptus camaldulensis (0.3 cm), Allium sativum (0.2 cm), Ceratonia siliqua (0.15 cm) and Amygdalus communis (0.15 cm) have the best antimicrobial activities against the bacterial mixture compared with the other fourteen tested plants. Furthermore, E. camaldulensis showed the strongest antimicrobial activity among the four plants. Also, A. sativum have the maximum anti-microbial action against all types of the tested bacteria. In addition, saps of E. camaldulensis and the mixture of E. camaldulensis and A. sativum have a strong ability to kill all types of the tested bacteria followed by the mixture of C. siliqua and A. sativum, the mixture of C. siliqua, A. sativum and E. camaldulensis and the mixture of A. communis, A. sativum and E. camaldulensis that have significant results as anti-microbial agents against most types of the tested bacteria. The results showed that A. sativum and the mixture of A. sativum and C. siliqua have the maximum antimicrobial affectivity against Staphylococcus aureus, whereas, Micrococcus luteus was strongly inhibited by E. camaldulensis, A. sativum, the mixture of E. camaldulensis and C. siliqua, the mixture of E. camaldulensis and A. sativum, and the mixture of E. camaldulensis, A. sativum and C. siliqua. Escherichia coli were efficiently inhibited by A. communis, A. sativum, and E. camaldulensis and also by the mixture of A. sativum and E. camaldulensis. Pseudomonas aeruginosa was inhibited in a significant amount by E. camaldulensis and A. sativum, whereas, Proteus vulgaris was strongly inhibited by the A. sativum. Bacillus subtilis was strongly inhibited by A. sativum, while, for the Klebsiella pneumoniae, most saps revealed an intermediate inhibition except the A. communis, which showed the lowest inhibition value. Therefore, the current study elucidated that E. camaldulensis, A. sativum, C. siliqua and A. communis are the best tested Palestinian plants containing the antibacterial agents against the tested bacterial types.

Biography:

W O Chu has graduated from the Department of Pharmacy Taipei Medical University (TMU) and Institute of Biomedical Engineering National Yang Ming University. She is an Adjunct Instructor at TMU and a Pharmacist in Taipei City Hospital, Department of Pharmacy. She has published more than 10 papers in the journal of Taiwan, 2 posters in International Pharmaceutical Federation (FIP), 1 poster in European Association of Hospital Pharmacists (EAHP), and got best poster award in the international pharma and clinical pharmacy congress.

Abstract:

Objective: Polypharmacy and potentially inappropriate medications (PIM) in the elderly complicates therapy, increases cost and is a challenge for healthcare agencies. Computerized warning system to reduce polypharmacy and PIM is a drug optimization process.
Methods: Using the healthcare information system (HIS) in Taipei City Hospital, we used a prospective before-and-after design among patients aged 80 years or older who had been prescribed 10 or more chronic medications (drugs prescribed for ≥28 days), visited three or more different physician office visits from November 1, 2013, through January 31, 2014 before the addition of the warning system and from April 1, 2014 through June 30, 2014 after the warning system was added. The EU(7)- PIM list was used to determine the potential inappropriateness of prescribed medications. Data were analyzed polypharmacy using Pair t test and PIM using multiple regressions by the SPSS 22. Value of P<0.05 was considered statistically significant.
Results: We enrolled 159 patients in our study after warning system setting, where the ratio of males: females were 89:70. The mean (SD) age of our patients was 85.8 (10.2) years. After the warning system was deployed, there was an immediate and sustained decrease in the rate of orders for the medications and PIM. The mean rate of prescribing medications dropped from 14.1 to 11.4 orders per day (SD 2.7; P<0.001) and physician visits number decreased from 3.5 to 3.1 per month (SD 0.5; P<0.001). PIM use was significantly associated with number of prescribing medications (p<0.001) and number of physician office visits in older adults (p=0.028). There was no evidence that this effect waned over time. Conclusions: Computerized warning system embedded into the healthcare information system (HIS), used in patients, can decrease the medication number and PIM quickly and specifically. The financial cost of polypharmacy involves both the direct expenditures for prescription medications as well as significant indirect costs related to hospitalization and treatment of severe adverse drug reactions. Pharmacovigilance is required by the patient, physician and pharmacist in thoroughly reviewing and reconciling the patient's medication regimen at every opportunity.

Biography:

Moawiah Khatatbeh has his expertise in public health and epidemiology and passion in improving the health and wellbeing. His philosophy is that our health is within the reach of our hands. In other words, most of health problems are avoidable. He has built this philosophy after years of experience in research, evaluation, and teaching both in hospitals and education institutions.

Abstract:

Statement of the Problem: There is abundant research about the effects of lipids on heart diseases in many countries, however, research about the association between fast food consumption and liver functions is lacking, especially in Arab countries. Therefore, detecting the extent to which students consume fast food meals highlights the way for people to encounter the associated risks. The purpose of this study is to highlight the magnitude of this risk factor among Jordanian university students.
Methodology & Theoretical Orientation: Data will be collected from voluntary subjects (students, n = 200) at Yarmouk University at two stages: The first stage involves using data collection tool asking about socio-demographic variables including age, gender, educational status and eating habits. In the second stage, 10 ml whole blood samples will be collected from each volunteer in the second day to test for lipid profile and liver function tests.
Findings: The research is ongoing and results are still not ready.
Conclusion & Significance: Junk and fast food is associated with increased BMI and impaired liver functions. This can
contribute to an increase risk of both hepatic and cardiovascular diseases.

Biography:

Zaid Altaany has completed his PhD in 2013 from Canada. After his PhD he perused his postdoctoral training in the Department of Biochemistry at Schulich School of Medicine & Dentistry, Western University, Canada. After completion of his postdoctoral training he was appointed as an Assistant professor in the Department of Medical Laboratory Sciences at Al Balqa University for one year. He was then appointed in 2016 as an Assistant Professor in the Department of Medical Sciences at the Faculty of Medicine at Yarmouk University in Jordan until know. His interests are focused on gasotransmitters, including hydrogen sulfide and nitric oxide and their impact on human health and cell signaling.

Abstract:

Statement of the Problem: Hydrogen sulfide (H2S) is well known gas that can endogenously produce in human body and have diverse impact on human health. However, the exogenous H2S is present in air and water, especially the sulfur spring in various concentrations. The long term exposure of exogenous H2S and its effect on inflammation control is not well studied. In our study we will examine the effect of H2S- emitted from sulfur spring and its correlation to anti-inflammatory response.
Methodology & Theoretical Orientation: Whole blood samples were collected from 100 individuals (exposed group) who lived permanently nearby El-HAMA springs for the last 10 years. Another 100 sample (control group) will be collected from Irbid area for analysis. Blood samples will be taken to measure inflammatory markers, H2S and NO concentration, proinflammatory cytokines including tumor necrosis factor α (TNF- α), interleukin IL-1β, interleukin IL-6, and interleukin IL-8).
Conclusion & Significance: This study would provide us with novel insight if cross-talk does in fact occur between long term H2S exposure and the anti inflammatory status and the development/or prevention of inflammatory diseases. Meanwhile we are conduction this research and results still in progress.

Biography:

Osama Yousef Abo Alrob, graduated from university of Alberta (PhD in basic medical sciences). I was supervised by Prof. Gary Lopaschuk and our lab is interested in heart and metabolic diseases such as obesity and diabetes. Currently, i am assistant professor in faculty of pharmacy. I teach courses related to Physiology and Pathophysiology.

Abstract:

Beneficial effects of resveratrol have attracted increasing interest in the last few years. The worldwide epidemic of diabetes has greatly increased the cost of treating both the disease and its numerous debilitating complications. We investigated the effects of weight loss and resveratrol on glucose homeostasis. Obesity was induced by feeding mice a high-fat (HF) diet (60% kcal from fat) for 10 weeks. After 10 weeks, mice were switched to a low-fat (LF) diet (12% kcal from fat; HF-LF) and treated with Resveratrol or maintained on an HF (HF-HF) and treated with Resveratrol for a further 6 weeks. After 16 weeks, HF-LF mice weighed less than HF-HF mice. cardiac hypertrophy was decreased and accompanied by increased SIRT1 and PGC1α expression in HF-LF mice. Impaired glucose tolerance had developed in HF mice at 10 weeks, as area under the curve (mmol/L · min) was significantly increased. At 16 weeks, glucose tolerance was improved in HF-LF mice compared with HF-HF group (43.1± 1.8 [n = 8] vs. 70.19± 1.4 [n =8]; P, 0.05). Western blot analysis showed a decreased phosphorylation of Akt as well as a decreased protein level of GLUT 2 in skeletal muscle of HFD fed mice. Treatment with Resveratrol enhanced insulin signaling and glucose uptake in HF-LF mice. Thus, lowering body weight by switching to LF diet and treatment with resveratrol is associated with decreased cardiac hypertrophy and improvements in both overall body insulin sensitivity and glucose homeostasis.

Biography:

Kaushal Kapadia is an expert clinical research professional with an experience of more than 10 years in clinical research operations. Apart from that an author for the book titled “Perspective on Clinical Research, India” also a best poster award winner at an international conference organized by OMICS in the year 2015 organized in Florida, USA.

Abstract:

Statement of the Problem: Clinical Research (CR) in developing countries, sponsored by developed countries has been under the lens since few years. However, hardly any empirical studies have been conducted on ethical issues in India. Hence limited knowledge is available to the public regarding the guidelines, ethical conduct, and also the ethical issues involved in clinical trials in India.
The Purpose of this Study: Considering the recent criticism on CR scenario in India, to encourage clinical trial participation, every individual should be entitled to complete information about the trial before involvement and about the outcome on completion. The purpose of this study is to explore and understand the perception, and understanding of clinical research amongst that population of India who are fit to directly or indirectly participate in CR.
Methodology & Theoretical Orientation: This ethics committee approved pan-India multi-strata study used multivariate questionnaire-based survey among 8416 individuals selected with snowball sampling; the participant population consisted of three groups: potential trial patients, parents of minor subjects, and healthy volunteers.
Findings: The study revealed lack of awareness in multiple parameters of clinical research among participants. Moderate awareness on questions of clinical trials benefit to society (67%) or new drug development (57.5%); face direct challenge from lack of knowledge (30% of the participants) about subject rights & safety measures taken by government regulatory authorities. Almost 58% of subjects were unaware of the amendments of guidelines regarding adequate compensation in case of adverse outcomes.
Conclusion & Significance: Ethical and scientific benefits are always intertwined in clinical research involving humans. Effective collaboration of ethics committee and sponsor’s team should be practiced to regain public faith and better conduct of trials. The study results call for initiatives like organizing trial summits involving patients, NGOs, sponsor’s representatives, apart from other stakeholders.